7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]-
Notopterol
CAS: 88206-46-6
Molecular Formula: C21H22O5
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]- - Names and Identifiers
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]- - Physico-chemical Properties
| Molecular Formula | C21H22O5 |
| Molar Mass | 354.4 |
| Density | 1.216 |
| Melting Point | 90-92°C |
| Boling Point | 546.7±50.0 °C(Predicted) |
| Specific Rotation(α) | 0°（c=1.99，chloroform） |
| Solubility | Soluble in methanol |
| Appearance | Colorless needle crystal (n-hexane/ethyl acetate) |
| pKa | 14.63±0.20(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD23701669 |
| Physical and Chemical Properties | White needle-like crystal, easily soluble in methanol, derived from the root of Notopterygium. |
| In vitro study | notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner. notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner. Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells. Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP. |
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]- - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]- - Reference
| Reference Show more | 1. Lili, Chen Yong, Zhang Mengwei, Huang Hongxia, Gao Shouhong, Chen Wansheng. Determination of 11 main components in UHPLC-MS experience prescription cold dampness lung decoction by Novel coronavirus pneumonia (COVID-19)/MS [J]. Journal of Pharmaceutical Practice, 2021,39(02):148-151 156. |
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]- - Reference Information
| biological activity | Notopterol is a coumarin extracted from N. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol has potential for use in acute myeloid leukemia (AML). |
| Use | notopterygietin is an extract of notopterygii Rhizoma, which has anti-proliferation and apoptosis activities. Pain medication. Has anti-inflammatory, antipyretic effect. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: analgesic effect, sedative effect, anti-inflammatory effect. |
Last Update：2024-04-09 20:48:19
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7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]-
丁嘧硫磷 标准品
Vitamin A Impurity 19 (Vitamin A EP Impurity B)
2-(2-fluorophenyl)-3H-iMidazo[4,5-c]pyridine Methanesulfonate
6-AMINO-5-BROMO-1-BUTYL-3-METHYL-1H-PYRIMIDINE-2,4-DIONE
3,8-DIOXO-2,3,5,6,7,8-HEXAHYDRO-4-ISOQUINOLINECARBOXAMIDE
Anthracene, 2,3-bis[2-(trimethylsilyl)ethynyl]-
4-chloromethyl-imidazolhydrochloride
2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid, methyl ester, (1R,3S,4S)-rel-
5,7-二羟基-4-甲基香豆素
丁嘧硫磷 标准品
Vitamin A Impurity 19 (Vitamin A EP Impurity B)
2-(2-fluorophenyl)-3H-iMidazo[4,5-c]pyridine Methanesulfonate
6-AMINO-5-BROMO-1-BUTYL-3-METHYL-1H-PYRIMIDINE-2,4-DIONE
3,8-DIOXO-2,3,5,6,7,8-HEXAHYDRO-4-ISOQUINOLINECARBOXAMIDE
Anthracene, 2,3-bis[2-(trimethylsilyl)ethynyl]-
4-chloromethyl-imidazolhydrochloride
2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid, methyl ester, (1R,3S,4S)-rel-
5,7-二羟基-4-甲基香豆素